IMUCLONE™ Free Protein S ELISA

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PRODUCTS | CLINICAL DIAGNOSTIC ASSAYS

Hemostasis

Name

REF

Protein S - IMUCLONE™ Free Protein S ELISA

842

Description:

Measures human Free Protein S in plasma. Protein S is a Vitamin K dependent glycoprotein synthesized in the liver. In normal human plasma, Protein S is present in two forms: Free Protein S (40% of total Protein S concentration) and Protein S complexed with C4b binding protein (C4b-BP). Only Free Protein S is active and acts as a cofactor for activated Protein C in the inactivation of fVa and fVIIIa. The determination of both Free Protein S and Total Protein S aids in the differential diagnosis of three types of Protein S deficiencies: Type 1 - reduced levels of both Total and Free Protein S antigen, Type II - normal Total and Free Protein S antigen but reduced activity, and Type III - normal Total Protein S levels but reduced Free Protein S levels. The ELISA is not reactive with Protein S-C4b-BP complexes.

Specifications:

Samples:	Citrate collected plasma, Serum
Sample Preparation:	1:50 dilution
Size:	100 µL
Assay Time:	1.5 hours
Standard Range:	0 - 100%

Precision:	Intra-assay CV < 8% Inter-assay CV < 10%
Lower Limit of Detection:	< 5%

Kit Components:

96-well antibody coated plate
Protein S standards
Protein S Control I
Protein S Control II
Sample diluent
Enzyme conjugate
Enzyme conjugate diluent
Substrate
Wash buffer
Stop solution

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